[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].
Identifieur interne : 001573 ( France/Analysis ); précédent : 001572; suivant : 001574[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].
Auteurs : B. Le Luyer [France] ; J F Mougenot ; L. Mashako ; P. Chapoy ; J P Olives ; A. Morali ; B. Chevallier ; J L Ginies ; C. Dupont ; M. DagorneSource :
- Archives francaises de pediatrie [ 0003-9764 ] ; 1990.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Alginates.
- chemical , pharmacology : Alginates.
- chemical , therapeutic use : Alginates.
- drug therapy : Gastroesophageal Reflux.
- Child, Preschool, Female, Humans, Hydrogen-Ion Concentration, Infant, Infant, Newborn, Male, Reference Values, Suspensions.
Abstract
Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.
PubMed: 2322080
Affiliations:
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pubmed:2322080Le document en format XML
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Le Luyer</name><affiliation wicri:level="3"><nlm:affiliation>Services de: Gastro-Entérologie pédiatrique, Centre Hospitalier, Le Havre.</nlm:affiliation><country>France</country><placeName><settlement type="city">Le Havre</settlement><region type="région" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><wicri:orgArea>Services de: Gastro-Entérologie pédiatrique, Centre Hospitalier</wicri:orgArea></affiliation></author><author><name sortKey="Mougenot, J F" sort="Mougenot, J F" uniqKey="Mougenot J" first="J F" last="Mougenot">J F Mougenot</name></author><author><name sortKey="Mashako, L" sort="Mashako, L" uniqKey="Mashako L" first="L" last="Mashako">L. Mashako</name></author><author><name sortKey="Chapoy, P" sort="Chapoy, P" uniqKey="Chapoy P" first="P" last="Chapoy">P. Chapoy</name></author><author><name sortKey="Olives, J P" sort="Olives, J P" uniqKey="Olives J" first="J P" last="Olives">J P Olives</name></author><author><name sortKey="Morali, A" sort="Morali, A" uniqKey="Morali A" first="A" last="Morali">A. Morali</name></author><author><name sortKey="Chevallier, B" sort="Chevallier, B" uniqKey="Chevallier B" first="B" last="Chevallier">B. Chevallier</name></author><author><name sortKey="Ginies, J L" sort="Ginies, J L" uniqKey="Ginies J" first="J L" last="Ginies">J L Ginies</name></author><author><name sortKey="Dupont, C" sort="Dupont, C" uniqKey="Dupont C" first="C" last="Dupont">C. Dupont</name></author><author><name sortKey="Dagorne, M" sort="Dagorne, M" uniqKey="Dagorne M" first="M" last="Dagorne">M. Dagorne</name></author></analytic><series><title level="j">Archives francaises de pediatrie</title><idno type="ISSN">0003-9764</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alginates (administration & dosage)</term><term>Alginates (pharmacology)</term><term>Alginates (therapeutic use)</term><term>Child, Preschool</term><term>Female</term><term>Gastroesophageal Reflux (drug therapy)</term><term>Humans</term><term>Hydrogen-Ion Concentration</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Reference Values</term><term>Suspensions</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Alginates</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Alginates</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Alginates</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Gastroesophageal Reflux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Hydrogen-Ion Concentration</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Reference Values</term><term>Suspensions</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement></list><tree><noCountry><name sortKey="Chapoy, P" sort="Chapoy, P" uniqKey="Chapoy P" first="P" last="Chapoy">P. Chapoy</name><name sortKey="Chevallier, B" sort="Chevallier, B" uniqKey="Chevallier B" first="B" last="Chevallier">B. Chevallier</name><name sortKey="Dagorne, M" sort="Dagorne, M" uniqKey="Dagorne M" first="M" last="Dagorne">M. Dagorne</name><name sortKey="Dupont, C" sort="Dupont, C" uniqKey="Dupont C" first="C" last="Dupont">C. Dupont</name><name sortKey="Ginies, J L" sort="Ginies, J L" uniqKey="Ginies J" first="J L" last="Ginies">J L Ginies</name><name sortKey="Mashako, L" sort="Mashako, L" uniqKey="Mashako L" first="L" last="Mashako">L. Mashako</name><name sortKey="Morali, A" sort="Morali, A" uniqKey="Morali A" first="A" last="Morali">A. Morali</name><name sortKey="Mougenot, J F" sort="Mougenot, J F" uniqKey="Mougenot J" first="J F" last="Mougenot">J F Mougenot</name><name sortKey="Olives, J P" sort="Olives, J P" uniqKey="Olives J" first="J P" last="Olives">J P Olives</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Le Luyer, B" sort="Le Luyer, B" uniqKey="Le Luyer B" first="B" last="Le Luyer">B. Le Luyer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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